Primary Antibody Matched Pairs
Cayman Chemical WB 4101hydrochlorIde 250mg
An α-AR antagonist; inhibits norepinephrine-induced contraction in isolated rat vas deferens (pA2 = 9.8); inhibits carbamoylcholine-induced contractions in isolated guinea pig taenia caeci (pA2 = 8.9)
ABclonal Technology SRPK1 Rabbit mAb
This gene encodes a serine arginine protein kinase specific for the SR (serine arginine-rich domain) family of splicing factors The protein localizes to the nucleus and the cytoplasm It is thought to play a role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors Alternative splicing of this gene results in multiple transcript variants Additional alternatively spliced transcript variants have been described for this gene but their full length nature have not been determined
ABclonal Technology IL1B Rabbit mAb
This gene encodes a protein in the interleukin 1 cytokine family produced by activated macrophages as a proprotein and activated by caspase 1 (CASP1 ICE) This cytokine mediates the inflammatory response and is involved in cell proliferation differentiation and apoptosis It induces cyclooxygenase-2 (COX2) in the CNS contributing to inflammatory pain hypersensitivity and is implicated in osteoarthritis Elevated IL-1B levels are found in patients with severe COVID-19 where it plays a role in lung damage due to the inflammatory response triggered by SARS-CoV-2 This gene is part of a cytokine gene cluster on chromosome 2 which includes eight other interleukin 1 family genes
ABclonal Technology Fatty Acid Synthase FASN
The enzyme encoded by this gene is a multifunctional protein Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA in the presence of NADPH into long-chain saturated fatty acids In some cancer cell lines this protein has been found to be fused with estrogen receptor-alpha (ER-alpha) in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha
ABclonal Technology 450 anti-Human CD79b/IgB
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component surface immunoglobulin (Ig) Surface Ig non-covalently associates with two other proteins Ig-alpha and Ig-beta which are necessary for expression and function of the B-cell antigen receptor This gene encodes the Ig-beta protein of the B-cell antigen component Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology 647 anti-Human/Monkey CD69
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors Expression of the encoded protein is induced upon activation of T lymphocytes and may play a role in proliferation Furthermore the protein may act to transmit signals in natural killer cells and platelets
ABclonal Technology GAD65/GAD2 Rabbit mAb
This gene encodes one of several forms of glutamic acid decarboxylase identified as a major autoantigen in insulin-dependent diabetes The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes This gene may also play a role in the stiff man syndrome Alternative splicing results in multiple transcript variants that encode the same protein
Cayman Chemical IGF2BP2 Long Isoformhumn50ug
Source: Recombinant human N-terminal His- and GST-tagged IGF2BP2 long isoform expressed in insect cells • Amino acids: 1-599 (full length) • MW: 94 kDa
Cayman Chemical PKN3 InhIbItr Compound 16 1mg
A serine/threonine protein kinase N3 inhibitor (IC50 = 14 nM); selective for this kinase over a panel of 234 kinases but does inhibit NLK, ACTR1, and RIPK2 at 1 µM, as well as GAK (IC50 = 74 nM in a BRET assay); inhibits viral replication in dengue virus-infected Huh7 cells (EC50 = 3.6 µM) without inducing cell death (CC50 = >10 µM)
Cayman Chemical PKN3 InhIbItr Compound 16 10mg
A serine/threonine protein kinase N3 inhibitor (IC50 = 14 nM); selective for this kinase over a panel of 234 kinases but does inhibit NLK, ACTR1, and RIPK2 at 1 µM, as well as GAK (IC50 = 74 nM in a BRET assay); inhibits viral replication in dengue virus-infected Huh7 cells (EC50 = 3.6 µM) without inducing cell death (CC50 = >10 µM)
Cayman Chemical PKN3 InhIbItr Compound 16 25mg
A serine/threonine protein kinase N3 inhibitor (IC50 = 14 nM); selective for this kinase over a panel of 234 kinases but does inhibit NLK, ACTR1, and RIPK2 at 1 µM, as well as GAK (IC50 = 74 nM in a BRET assay); inhibits viral replication in dengue virus-infected Huh7 cells (EC50 = 3.6 µM) without inducing cell death (CC50 = >10 µM)
Abcam Terpendole C, ACAT1 and ACAT2 inhibitor, 250UG
MW 519.7 Da, Purity >95%. Non-selective ACAT1 and ACAT2 inhibitor (IC₅₀ values are 10 and 10 μM respectively). Terpendole E (ab144368) analog. Potently inhibits cholesteryl ester formation (IC₅₀ = 0.46 μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Terpendole C, ACAT1 and ACAT2 inhibitor, 1MG
MW 519.7 Da, Purity >95%. Non-selective ACAT1 and ACAT2 inhibitor (IC₅₀ values are 10 and 10 μM respectively). Terpendole E (ab144368) analog. Potently inhibits cholesteryl ester formation (IC₅₀ = 0.46 μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Pyripyropene A, ACAT2 inhibitor, 250UG
MW 581.6 Da, Purity >95%. Potent, selective ACAT2 inhibitor (IC₅₀ = 70 nM). Shows antihypercholesterolemic and antiatherosclerotic effects in vivo. Orally active.
The product is subject to the following: Abcam Restricted Use Statement